-
A June, 2004, article by
Dr. Cui and Dr.
Willingham,
"The effect of aging on
cellular immunity
against cancer in SR/CR
mice,"
published in the journal
Cancer Immunology,
Immunotherapy.
-
Dr. Cui wrote an essay,
"The
winding road to the
discovery of the SR/CR
mice"
for the journal Cancer
Immunity, published by
the Academy of Cancer
Immunology in October,
2003.
-
The
first major scientific
publication based on
this research
was published in the
journal Proceedings of
the National Acadamy of
Sciences:
Cui Z, Willingham MC,
Hicks AM,
Alexander-Miller MA,
Howard TD, Hawkins GA,
Miller MS, Weir HM, Du
W, DeLong CJ.
Spontaneous regression
of advanced cancer:
identification of a
unique genetically
determined,
age-dependent trait in
mice.
Proc Natl Acad Sci U S
A. 2003 May
27;100(11):6682-7.
Abstract:
We have established and
studied a colony of mice
with a unique trait of host
resistance to both ascites
and solid cancers induced by
transplantable cells. One
dramatic manifestation of
this trait is age-dependent
spontaneous regression of
advanced cancers. This
powerful resistance
segregates as a single-locus
dominant trait, is
independent of tumor burden,
and is effective against
cell lines from multiple
types of cancer. During
spontaneous regression or
immediately after exposure,
cancer cells provoke a
massive infiltration of host
leukocytes, which form
aggregates and rosettes with
tumor cells. The cytolytic
destruction of cancer cells
by innate leukocytes is
rapid and specific without
apparent damage to normal
cells. The mice are healthy
and cancer-free and have a
normal life span. These
observations suggest a
previously unrecognized
mechanism of immune
surveillance, which may have
potential for therapy or
prevention of cancer.
Full text of the article
can be read online
here.
A
printable version of the
article can be downloaded
here.
Selected Coverage of May 8,
2006 Announcement
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Injected Cells Cure
Tumors in Mice, Los
Angeles Times, May 9,
2006-05-09
-
A Strain of Mice Appears
Able to Resist Cancer
Cells, New York Times,
May 9, 2006
-
Cancer Resistance Found
to be Transferable in
Mice, Scientific
American.com May 9, 2006
-
Researchers Cure Lethal
Cancer in Mice, Voice of
America, May 8, 2009
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Mice Put Cancer on Ice,
Newsday, May 9, 2006
-
Cell Therapy Treatment
is Curing Cancer in
Mice, Winston-Salem
Journal, May 9, 2006
Some Related Articles and
Press Coverage from April
2003 Announcement:
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